M-position pyridine quaternary ammonium salt substituted BODIPY compound as well as preparation method and medicinal application thereof

• Main Authors: ZHAO WEILI, LIN GUANGYU, DONG XIAOCHUN, HU MEI
• Format: Patent
• Language: Chinese; English
• Published: 04.04.2023
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention belongs to the technical field of drug synthesis, and relates to a meta-position pyridine quaternary ammonium salt substituted BODIPY compound as well as a preparation method and medicinal application thereof, in particular to a meso-position 3-pyridine quaternary ammonium salt substituted BODIPY compound as well as a preparation method and application thereof. Photosensitization efficiency and in-vitro and in-vivo bacteriostatic activity tests show that the compound has good antibacterial activity and can be used for preparing a novel BODIPY (boron dipyrromethene) photosensitizer containing pyridine quaternary ammonium salt and further preparing a novel antibacterial drug. 本发明属药物合成技术领域，涉及间位吡啶季铵盐取代的BODIPY化合物及其制备方法和药用用途，具体涉及meso位3-吡啶季铵盐取代BODIPY化合物及其制备方法和应用。本发明的化合物通过光敏化效率以及体外体内抑菌活性测试显示，所述的化合物具有良好的抗菌活性，可用于制备新型含吡啶季铵盐的氟硼二吡咯(BODIPY)类光敏剂，及进一步制备新的抗菌药物。