Inhibitor of receptor interacting protein kinase 1 as well as preparation method and application of inhibitor

• Main Authors: LIN LIZHI, WANG MINGHUI, WANG JINXIN, NIU AO, ZHOU WENJIA, SHI JUNWEI
• Format: Patent
• Language: Chinese; English
• Published: 04.04.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention belongs to the field of pharmacology, and particularly relates to an inhibitor of receptor-interacting protein kinase 1 as well as a preparation method and application of the inhibitor. Specifically, the invention relates to a spiro compound with a structure of a general formula (I), or a pharmaceutically acceptable salt, a stereoisomer or a prodrug thereof. A series of spiro compounds are synthesized for the first time, the series of compounds are new compounds, and the preparation method is a brand new reaction route. The compound has the activity of inhibiting RIPK1 kinase and can be used as a drug or a prodrug for preventing and/or treating RIPK1 related diseases. 本发明属于药物学领域，具体涉及一种受体相互作用蛋白激酶1的抑制剂及其制备方法、应用。具体为一种化合物具有通式（I）结构的螺环类化合物或者其药学上可接受的盐或立体异构体或其前药；本发明首次合成一系列螺环类化合物，该系列化合物为新化合物，且制备方法也是全新反应路线。其具有制备抑制RIPK1激酶活性，可作为治疗预防和/或治疗RIPK1相关疾病的药物或前药。