Natural TARC/CCL17 and MDC/CCL22 inhibitors as well as preparation and application thereof

• Main Authors: TIAN HONGRU, YANG DEPO, LI HAILING
• Format: Patent
• Language: Chinese; English
• Published: 04.04.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention belongs to the technical field of biological medicines, and particularly relates to TARC/CCL17 and MDC/CCL22 inhibitors with natural sources as well as preparation and application of the TARC/CCL17 and MDC/CCL22 inhibitors. The invention discloses a TARC/CCL17 and MDC/CCL22 inhibitor with a natural source, namely a Citrus chachiensis fruit extract. The Citrus chachiensis fruit extract can inhibit expression of TARC/CCL17 and MDC/CCL22 which are significantly related to inflammatory diseases, has an obvious curative effect on inflammatory diseases such as atopic dermatitis, can significantly improve skin lesion and pathological thickening of mice suffering from atopic dermatitis induced by 2, 4-dinitrofluorobenzene, alleviates mastocyte infiltration, reduces the pruritus frequency of the mice, and has a good application prospect. And the traditional Chinese medicine composition has the effect of treating atopic dermatitis, and has the advantages of exact curative effect, obvious effect and wide a