Application of Hilnc or signaling pathway containing Hilnc as target for regulating lipid metabolism

• Main Authors: JIANG YI'AO, ZHAO YUN, PENG JIAYIN
• Format: Patent
• Language: Chinese; English
• Published: 31.03.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The invention provides an application of a Hilnc (Hedgehog signal-induced long-chain non-coding RNA) or a signal channel containing the Hilnc (Hedgehog signal-induced long-chain non-coding RNA) as a target for regulating and controlling lipid metabolism. The Hilnc plays an important role in lipid metabolism mediated by Hh. According to the invention, an Hh signal channel and lipid metabolism are associated with the lncRNAs for the first time, which is an important progress of research on Hh signal transduction, lncRNAs, cell metabolism and lipid metabolism. 本发明提供了一种Hilnc(Hedgehog信号诱导的长链非编码RNA)或包含其的信号通路作为调控脂质代谢的靶标的应用。Hilnc在Hh介导的脂质代谢中起重要作用。本发明中首次将Hh信号通路和脂质代谢与lncRNAs加以关联，是Hh信号转导、lncRNAs、细胞代谢和脂质代谢研究的重要进展。