Bacterium for degrading intracellular tumor proliferation protein

• Main Authors: XU HAIHENG, CHEN YIYUN, XIONG SHUQIN, WU JINHUI
• Format: Patent
• Language: Chinese; English
• Published: 31.03.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The invention relates to preparation and application of a medicine for treating tumors based on specific degradation of intracellular proteins by a bacterial vector, and belongs to the field of biological medicines. According to the present invention, the bacteria are adopted as the carrier to express the fusion protein capable of specifically degrading the intracellular protein in the targeting manner, such that the cell immunogenicity death can be caused while the tumor cell proliferation is blocked so as to achieve the tumor treatment purpose; 本发明一种基于细菌载体特异性降解胞内蛋白质治疗肿瘤的药物制备和应用，属于生物医药领域。本发明利用细菌作为载体，表达能够特异性靶向降解胞内蛋白质的一种融合蛋白，阻断肿瘤细胞增殖的同时能够引起细胞免疫原性死亡，以达到肿瘤治疗的目的。