Inhibitors of APOL1 and uses thereof

The present disclosure provides compounds of Formula (I), deuterated derivatives of these compounds, and pharmaceutically acceptable salts of these compounds and derivatives, compositions comprising the same, and methods of using the same, including in the treatment of APOL1 mediated kidney disease....

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Main Authors HAMMEL MARKUS, TAY CHRISTOPHER E, NICOLAS, OLIVIER, DENIS, FR, KRUEGER ERIC B, COME, JON, H, MALTAIS FRANCOIS, LEFORT BENJAMIN, DAKIN LES A, RIC, DORSCH WILLIAM A, NANTHAKUMAR, SHANKAR, SHANKAR, D, CAO JIAN, FORTIER, ARNAUD
Format Patent
LanguageChinese
English
Published 28.03.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present disclosure provides compounds of Formula (I), deuterated derivatives of these compounds, and pharmaceutically acceptable salts of these compounds and derivatives, compositions comprising the same, and methods of using the same, including in the treatment of APOL1 mediated kidney disease. 本公开提供了式(I)的化合物，这些化合物的氘化衍生物，以及这些化合物和衍生物的药学上可接受的盐，包含其的组合物，以及使用其的方法，包括在治疗APOL1介导的肾脏疾病中的用途。
Bibliography:Application Number: CN202180049447