Kinase inhibitors

Disclosed herein are 1H-indole-7-carboxamide derivatives as protein kinase inhibitors, particularly Bruton's tyrosine kinase (BTK) inhibitors, pharmaceutical compositions comprising them, processes for their preparation and the use of such protein kinase inhibitors for the treatment or preventi...

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Bibliographic Details
Main Authors ARORA NIDHI, COBURN CRAIG ALAN, KUMAR DANGA VIJAY, BUZARD DANIEL JOHN
Format Patent
LanguageChinese
English
Published 28.03.2023
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed herein are 1H-indole-7-carboxamide derivatives as protein kinase inhibitors, particularly Bruton's tyrosine kinase (BTK) inhibitors, pharmaceutical compositions comprising them, processes for their preparation and the use of such protein kinase inhibitors for the treatment or prevention of diseases, disorders and conditions associated with kinase function. In particular, the present invention relates to selective BTK inhibitors. 本文公开了作为蛋白激酶抑制剂，特别是布鲁顿酪氨酸激酶(BTK)抑制剂的1H-吲哚-7-甲酰胺衍生物、包含它们的药物组合物、用于制备它们的方法以及此类蛋白激酶抑制剂用于治疗或预防与激酶功能相关的疾病、障碍和病症的用途。具体地，本发明涉及选择性BTK抑制剂。
Bibliography:Application Number: CN202180048117