Hydroxamic acid compound as well as derivative, preparation method, pharmaceutical composition and application thereof

• Main Authors: SHENG TIANCHENG, SONG SHIYU, CHEN YADONG, LU SHUAI, WAN WEIQI, JIA KUN, WANG ZHIJIE, HUANG FEI, CHENG ZITIAN, LU TAO
• Format: Patent
• Language: Chinese; English
• Published: 24.03.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses a hydroxamic acid compound as well as a derivative, a preparation method, a pharmaceutical composition and application thereof. The structure of the compound is shown as a formula I. The hydroxamic acid compound derivative relates to pharmaceutically acceptable salts of the compound. The hydroxamic acid compound and the derivative thereof have an efficient inhibition effect on FLT3 and HDAC, and can be used for preparing drugs for diseases related to FLT3 and HDAC. The prepared medicine can exert efficacy at the molecular level and the cellular level, and the problems that an existing single medicine is poor in curative effect and prone to drug resistance, untoward effects caused by combination of different medicines, patient compliance and the like are solved. In addition, the synthesis method of the compound is wide in applicability and simple and convenient to operate. 本发明公开了一种氧肟酸类化合物及其衍生物、制备方法、药物组合物和应用。该化合物结构如式I，该氧肟酸类化合物衍生物涉及所述化合物药学上可接受的盐。该氧肟酸类化合物及其衍生物对FLT3、HDAC具有高效的抑制作用，可用于制备与FLT3