SIRP [alpha] Fc fusion protein targeting tumor matrix collagen and application of SIRP [alpha] Fc fusion protein

• Main Authors: KURBAN, KUDREDI, WANG SONGNA, LIU JIAYANG, YE LI
• Format: Patent
• Language: Chinese; English
• Published: 21.03.2023
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention belongs to the technical field of medical biology. Relates to SIRP alpha Fc fusion protein targeting tumor matrix collagen and application of the SIRP alpha Fc fusion protein, a gene recombination method is utilized, collagen-binding domain (CBD) with collagen binding specificity is expressed at the C end of an Fc structural domain of the SIRP alpha Fc fusion protein in a fusion mode, and the SIRP alpha Fc fusion protein (CBD-SIRP alpha Fc fusion protein) capable of targeting solid tumor tissue is prepared. The fusion protein can target SIRP alpha Fc to tumor tissues by utilizing high exposure of subcutaneous collagen in a tumor matrix and a blood vessel, so that macrophages are started to phagocytize tumor cells, and the curative effect of the SIRP alpha Fc is improved; meanwhile, the combination of SIRP alpha Fc and healthy cells is reduced, the safety of the SIRP alpha Fc is improved, and the pharmacokinetics of the SIRP alpha Fc is improved. The fusion protein can be used for preparing medic