Antibacterial oil-in-water emulsions

• Main Author: D.C. WRIGHT
• Format: Patent
• Language: Chinese; English
• Published: 21.07.2004
• Edition: 7
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TRAPPING

本发明公开了一种水包油抗微生物乳液，它包含一个选自如下种类的，作为主要乳化剂的成分：甘油一油酸酯，甘油三油酸酯，甘油一月桂酸酯，和甘油二月桂酸酯，还包含一个作为正电荷生成剂的，具有C#-[12]-C#-[16]链的阳离子含卤素化合物。该乳液还可以任选地包含一个固醇，优选地是植物固醇。用于本发明优选的具有C#-[12]-C#-[16]链的阳离子含卤素化合物包括：十六烷基吡啶�氯化物，十六烷基吡啶�溴化物，十六烷基三甲基铵溴化物，十六烷基二甲基乙基铵溴化物和氯苄烷铵。该抗微生物乳液可以以药剂的形式用于抑制多种传染性病原体的生长，包括细菌、真菌和病毒。 An antibacterial oil-in-water emulsion for inhibiting the growth of Helicobacter pylori is disclosed. The oil-in-water emulsion of the invention comprises droplets of an oily discontinuous phase dispersed in a continuous phase. The oily discontinuous phase contains an oil carrier and a glycerol ester selected from the group consisting of glycerol monooleate and glycerol monostearate. The emulsion can be positively charged, negatively charged or chargeless. In one embodiment, the emulsion is positively charged and further comprises a cationic halogen-containing compound having a C12-C16 chain as a positive charge producing agent. In another embodiment, the emulsion is negatively charged and further comprises an negative charge producing agent having a C12-C22 chain. The disclosed emulsions can be administered to individuals, for example, orally, to treat or prevent Helicobacter pylori infections.