Lactobacillus brevis and application thereof in resisting cervical cancer

• Main Authors: TAN DINGJI, HE LIANG, YANG HONGYING
• Format: Patent
• Language: Chinese; English
• Published: 17.03.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; DAIRY PRODUCTS, e.g. MILK, BUTTER, CHEESE; ENZYMOLOGY; FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MAKING THEREOF; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MILK OR CHEESE SUBSTITUTES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; PROCESSES USING MICROORGANISMS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES; VINEGAR; WINE

The invention discloses lactobacillus brevis and application thereof in resisting cervical cancer. The lactobacillus brevis provided by the invention is specifically lactobacillus brevis YNH, and the preservation number of the lactobacillus brevis is CGMCC (China General Microbiological Culture Collection Center) No.24368 in the General Microbiological Culture Collection Center of the China Committee for Culture Collection of Microorganisms. Experiments prove that the Lactobacillus brevis YNH has the effects of reducing the proliferation activity of cervical cancer Hela cells, retarding the Hela cell cycle in the S period, reducing the mitochondrial membrane potential of the Hela cells and promoting the apoptosis of the Hela cells. The Lactobacillus brevis YNH can inhibit Hela cell proliferation, promote apoptosis and inhibit proliferation of cervical cancer subcutaneous tumor in nude mice by inhibiting a PI3K/AKT signal channel, has good inhibitory activity on cervical cancer Hela cells, can be used for regu