普通拟杆菌及其组合物在辅助癌症免疫治疗中的应用

• Format: Patent
• Language: Chinese
• Published: 20.10.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROCESSES USING MICROORGANISMS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

本发明提供一种肠道菌，具体为普通拟杆菌(Bacteroides vulgatus)菌株，保藏号CGMCC No.22924及其在预防肿瘤和辅助肿瘤免疫治疗中的应用。所述菌能够与基于抗PD-1的肿瘤治疗联合使用而增加抗肿瘤效果，以及与治疗肿瘤的其他抗体药物联合使用。所述菌可在受试者体内定植，并抑制荷瘤小鼠肿瘤生长。所述普通拟杆菌及其组合物能够用于抗肿瘤免疫治疗，尤其是在抗PD1相关的免疫检查点阻断治疗中提高受试者的治疗响应率。 The invention provides an intestinal bacterium, in particular to a Bacteroides vulgaris strain with the preservation number of CGMCC (China General Microbiological Culture Collection Center) No.22924 and application of the Bacteroides vulgaris strain to prevention of tumors and auxiliary tumor immunotherapy. The bacteria can be used in combination with anti-PD-1-based tumor therapy to increase the anti-tumor effect, and can be used in combination with other antibody drugs for treating tumors. The bacteria can be colonized in a subject and inhibit tumor growth of a tumor-bearing mouse. The bacteroides vulgaris and the composition thereof can be used for anti-tumor immunotherapy, and particularly can be used for improving the treatment response rate of a subject in anti-PD1 related immune checkpoint