Method for preparing mupiravir intermediate by one-pot method

The invention belongs to the technical field of medicine synthesis, and particularly relates to a method for preparing a mupiravir intermediate ((3AR, 4R, 6R, 6AR)-6-(4-(hydroxylamine)-2-oxazine-1 (2H)-methyl)-2, 2-dimethyltetrahydrofuran [3, 4-D] [1, 3] dioxol-4-yl) methyl isobutyrate by a one-pot...

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Bibliographic Details
Main Authors LI YUEDONG, NIE SHENGWEI, SU TIANHUI, YUE YUANHAO, NIU YUCHENG, YANG YANJUN
Format Patent
LanguageChinese
English
Published 14.03.2023
Subjects
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Summary:The invention belongs to the technical field of medicine synthesis, and particularly relates to a method for preparing a mupiravir intermediate ((3AR, 4R, 6R, 6AR)-6-(4-(hydroxylamine)-2-oxazine-1 (2H)-methyl)-2, 2-dimethyltetrahydrofuran [3, 4-D] [1, 3] dioxol-4-yl) methyl isobutyrate by a one-pot method. According to the method, the synthetic route is simple to operate, the reaction post-treatment step is simplified, the use of solvent types is reduced, the raw material cost and the production cost are low, the amount of generated mother liquor is small, the production is more environment-friendly, and the obtained mupiravir intermediate ((3AR, 4R, 6R, 6AR)-6-(4-(hydroxylamine)-2-oxapyrimidine-1 (2H)-methyl)-2, 2-dimethyltetrahydrofuran [3, 4-D] [1, 2-a] pyrimidine-2-ketone) is suitable for industrial production. 3] dioxol-4-yl) methyl isobutyrate is high in liquid phase purity and yield, and is more suitable for industrial mass production. The purity of the produced mupiravir liquid phase in the next step
Bibliography:Application Number: CN202211521181