Preparation method of infelglatinib

• Main Authors: SONG XUEPAN, ZHANG SHAN, LIU JIN, LIU ZHIPING, XIAO WENSONG, HUANG DONG, DONG HAILI
• Format: Patent
• Language: Chinese; English
• Published: 14.03.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The invention relates to infelglatinib, in particular to a novel method for preparing the infelglatinib. The method comprises the following steps: 1) reacting a compound I (the chemical name is 4, 6-difluoropyrimidine) with methylamine to obtain an intermediate II; 2) reacting the intermediate II with phenyl chloroformate to obtain an intermediate III; 3) carrying out substitution reaction on the compound III and the compound IV to obtain an intermediate V; and (4) carrying out substitution reaction on the intermediate V and the intermediate VI to obtain the final product infinicoglatinib. The process route provided by the invention has the advantages of short route, cheap and easily available raw materials, simplicity and convenience in operation, mild conditions, high reaction yield, avoidance of use of highly toxic products, environmental friendliness and easiness in industrial production. 本发明涉及本发明涉及英菲格拉替尼，具体涉及一种制备英菲格拉替尼的新方法。该方法包括如下步骤：1)化合物I(化学名为：4,6-二氟嘧啶)与甲胺反应，得到中间体II；2)中间体II与氯甲酸苯酯反应，得到中间体III；3)化合物III与IV发