Synthesis method of polyfluorinated compound containing gem-difluoroolefin structure

• Main Authors: LIANG YUFENG, GUAN YUQIU, WANG TIANZHANG
• Format: Patent
• Language: Chinese; English
• Published: 14.03.2023
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The invention relates to a synthesis method of a multi-fluorine compound containing a gem-difluoroolefin structure, which comprises the following steps: mixing trifluoromethyl olefin (I) with bromo difluoroacetate in an organic solvent, adding a catalyst iron trifluoromethanesulfonate and a ligand 1, 2, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3 The polyfluorinated compound (III) with the gem-difluoroolefin structure is prepared through a reaction in the presence of manganese powder and under the protection of nitrogen, R1 is selected from hydrogen, alkyl, alkoxy, aryl, substituted aryl and heterocyclic aryl, and R2 is selected from carbonyl, ester group, amido, substituted amido and phosphonate group; the organic solvent is dimethyl sulfoxide, N, N-dimethyl formamide, N, N-dimethyl acetamide or N-methyl pyrrolidone, and the organic solvent is N, N-dimethyl formamide, N, N-dimethyl acetamide or N-methyl pyrrolidone. 本发明涉及一种含偕二氟烯烃结构的多氟化合物的合成方法，在有机溶剂中将三氟甲基烯烃(I)与二氟溴乙酸酯混合，加入催化剂三氟甲磺酸铁和配体1,10-邻菲罗啉后在锰粉存在并有氮气保