Ramelteon oral dissolving film agent and preparation method thereof

• Main Authors: LIU YINGFANG, KE XINGFA, NAHUZ, ELIYA, PENG XINBING, XU XIANYING, LUO GUANGHUA, HUANG YANGBIN, SHEN FENGMEI
• Format: Patent
• Language: Chinese; English
• Published: 14.03.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to the technical field of pharmaceutical preparation preparation, in particular to a ramelteon oral dissolving film agent and a preparation method thereof. The ramelteon oral soluble film agent is prepared from a main drug and auxiliary materials in percentage by weight, the main drug ramelteon accounts for 5%-30%, and the auxiliary materials comprise 30%-85% of a polymer film-forming material, 4%-20% of a plasticizer, 0-20% of a solubilizer, 3%-15% of a flavoring agent and 0.05%-3% of a coloring agent. The ramelteon oral soluble film agent is simple in preparation process, has the advantages of being prepared in dosage, easy to swallow, rapid in effect taking, free of water and the like, can be taken half an hour before sleep, free of water or chewing, and can be rapidly dissolved when encountering saliva in the mouth, so that the medicine is rapidly absorbed through mucous membranes in the oral cavity, the first-pass effect of the medicine is reduced, and the curative effect of the med