Tranexamic acid injection as well as preparation method and application thereof

• Main Authors: XIONG YUHANG, WANG JING, YAO HUIPING, BAI ZHONG, XIE JUN, YUE QIANG, TU PEIHUA
• Format: Patent
• Language: Chinese; English
• Published: 14.03.2023
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to a tranexamic acid injection as well as a preparation method and application thereof. On one hand, each 100ml of the tranexamic acid injection comprises 5-15g of tranexamic acid and injection water added to the total amount. The tranexamic acid injection is prepared by a method comprising the following steps: providing a tranexamic acid crude drug; the preparation method comprises the following steps: adding 50-80% of water for injection according to the prescription dosage, tranexamic acid according to the prescription dosage and optional other auxiliary materials into a concentrated mixing tank, and stirring until the materials are dissolved; adding activated carbon, preserving heat and stirring, filtering and decarburizing, transferring into a diluting tank, cooling to room temperature, and adding water to nearly full amount; and adjusting the pH value to 7.2 +/-0.5 by using an acid-base regulator, adding water to the total amount, filtering by using a microfiltration membrane, fill