Pyrrolo [2, 3-f] indazole and 2, 4, 5, 10-tetraazatricyclo [7.3. 0.03, 7] dodeca-1, 3 (7), 5, 8, 11-pentaene derivatives as alpha-1-antitrypsin modulators for treatment of alpha-1-antitrypsin deficiency (AATD)

• Main Authors: BRODNEY MICHAEL AARON, TAPLEY, THOMAS, L, THOMSON STEPHEN ANDREW, SWEET, RAYMOND, J, COTTRELL KEVIN MICHAEL, SUH JUNGWON, FANNING, LEV, T.D, DAMANIEZ, VINCENT, HURLEY, DENNIS, JAMES, MAXWELL, JOHN, P, ZAKI MAGED, FIMONIARI, ROBERT, F., JR, HALL ANDREW BRIAN, BOYD MICHAEL J, GARCIA BALANTES PEDRO MANUEL, JONES PHILIP, BOUCHER DAVID MICHAEL, KESAVAN SRIRAM, GRAY, ROBERT, L., JR, NUCHANT PETER M, JOHNSON, MICHAEL, A., JR, GIROUX SIMON
• Format: Patent
• Language: Chinese; English
• Published: 10.03.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Disclosed herein are pyrrolo [2, 3-f] indazole and 2, 4, 5, 10-tetraazatricyclo [7.3. 0.03, 7] dodeca-1, 3 (7), 5, 8, 11-pentaene derivatives as alpha-1-antitrypsin modulators for use in the treatment of alpha-1-antitrypsin deficiency (AATD). 本文公开了作为用于治疗α-1抗胰蛋白酶缺乏症(AATD)的α-1-抗胰蛋白酶调节剂的吡咯并[2,3-f]吲唑和2,4,5,10-四氮杂三环[7.3.0.03,7]十二碳-1,3(7),5,8,11-五烯衍生物。