Viral delivery vehicle selection

Delivery vehicle libraries and methods of use thereof are provided herein. The delivery vehicle provided comprises different variants of a virus and a nucleic acid sequence encoding a different virally identifying barcode region having specificity for each viral variant and a nucleic acid sequence e...

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Bibliographic Details
Main Authors JENSEN, MICHAEL, BECH, FUENTES DAVID
Format Patent
LanguageChinese
English
Published 07.03.2023
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:Delivery vehicle libraries and methods of use thereof are provided herein. The delivery vehicle provided comprises different variants of a virus and a nucleic acid sequence encoding a different virally identifying barcode region having specificity for each viral variant and a nucleic acid sequence encoding at least one reporter gene. The methods provided herein include methods of identifying a vehicle effective to target specific cell types. 本文提供了递送媒剂文库和其使用方法。所提供的递送媒剂包含病毒的不同变体和编码对每种病毒变体具有特异性的不同病毒鉴定性条形码区域的核酸序列以及编码至少一个报告基因的核酸序列。本文所提供的方法包含鉴定有效靶向特定细胞类型的媒剂的方法。
Bibliography:Application Number: CN202180034056