CD19 directed chimeric antigen receptor t cell compositions and methods and uses thereof

• Main Authors: GILAVUZ, NATALIE, WESTBY MICHAEL, WU KENNETH, KUGLER DAVID G, BRIGGS ANDREW W, BASHOUR KEENAN, SALMEN, ROBERT, A, BATURVYCH OLEKSANDR, POLTORAK, MARK, P, GEMELO LOTHAR, HAIGH KEVIN, CHEN CHUNHUA, WAHLEN DAVID, CASPARI ROBERT G, STEINBERG CHRISTIAN, BURGESS MICHAEL
• Format: Patent
• Language: Chinese; English
• Published: 07.03.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Provided, in some aspects, are cellular compositions for treating subjects having diseases and conditions, such as non-Hodgkin's lymphoma (NHL), as well as related methods, compositions, uses, and articles of manufacture. In some embodiments, the disease or condition is B cell non-Hodgkin's lymphoma (B cell NHL). The cells generally express recombinant receptors, such as chimeric antigen receptors (CARs), for targeting antigens, such as CD19, on cells of the lymphoma. 在一些方面提供了用于治疗患有疾病和病症如非霍奇金淋巴瘤(NHL)的受试者的细胞组合物，以及相关方法、组合物、用途和制品。在一些实施方案中，所述疾病或病症是B细胞非霍奇金淋巴瘤(B细胞NHL)。所述细胞通常表达用于靶向所述淋巴瘤的细胞上的抗原如CD19的重组受体如嵌合抗原受体(CAR)。