Novel crystal form of isoquinoline sulfonyl derivative as well as preparation method and application of novel crystal form

• Main Authors: CHU GUOBIAO, YIN HUIJUN, ZHANG ZHIGANG, HU YANG, ZHAO XIN, DOU HAOSHUAI, WANG LUFENG
• Format: Patent
• Language: Chinese; English
• Published: 03.03.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to a novel crystal form of an isoquinoline sulfonyl derivative as well as a preparation method and application thereof. Specifically, the invention relates to a crystal form D, a crystal form B and a crystal form C of a compound as shown in a formula (I), and a preparation method and application of the crystal form D, the crystal form B and the crystal form C. The crystal form provided by the invention has good hygroscopicity and stability, and is favorable for being prepared into a medicine for clinically treating diseases related to Rho kinase activity, especially idiopathic pulmonary fibrosis. 本发明涉及异喹啉磺酰衍生物新晶型及其制备方法和用途。具体而言，本发明涉及式(I)所示化合物的D晶型、B晶型和C晶型，以及它们的制备方法和用途。本发明提供的晶型具有良好的引湿性和稳定性，有利于制备成药物用于临床治疗与Rho激酶活性相关的疾病特别是特发性肺纤维化。