Preparation method of narrow-distribution polymer vesicles

• Main Authors: LUO WANRU, ZHAN JILAI, YU QIANQIAN, WANG LINGE
• Format: Patent
• Language: Chinese; English
• Published: 28.02.2023
• Subjects: APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBONFILAMENTS; CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS,THREADS, FIBRES, BRISTLES OR RIBBONS; HUMAN NECESSITIES; HYGIENE; MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OFARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES ORRIBBONS; MEDICAL OR VETERINARY SCIENCE; NATURAL OR ARTIFICIAL THREADS OR FIBRES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPINNING; TEXTILES

The invention discloses a preparation method of narrow-distribution polymer vesicles, and belongs to the technical field of polymer vesicle preparation. The method comprises the following steps: 1) dissolving a block copolymer or the block copolymer and a required loaded drug in an organic solvent, and obtaining a spinning solution after full dissolution; (2) spinning the spinning solution through a high-voltage electrostatic spinning method to obtain fibers with diameters distributed in a range of 0.5-10 microns; (3) quenching and breaking the fibers obtained in the step (2) to obtain short fibers with the length of 0.5-5mm; and 4) adding water into the short fibers obtained in the step 3), and carrying out a rehydration reaction to obtain the polymer vesicles. The method disclosed by the invention is simple, low in cost and good in repeatability, and can be used for large-scale preparation and production of the narrow-distribution polymer vesicles. 本发明公开了一种窄分布高分子囊泡的制备方法，属于高分子囊泡制备的技术领域。本发明方法包括如下步骤：1)将嵌段共聚物或嵌