Preparation method of antiviral nucleoside analogue

The invention belongs to the field of medicines, and particularly relates to a preparation method of an antiviral nucleoside analogue, which comprises the following steps: reacting a compound of formula (VIII) with a reagent A to generate a compound of formula (VII); reacting the compound in the for...

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Bibliographic Details
Main Authors TIAN, GUANGHUI, XU WANBIN, LI JIAN, XIE YUANCHAO
Format Patent
LanguageChinese
English
Published 28.02.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention belongs to the field of medicines, and particularly relates to a preparation method of an antiviral nucleoside analogue, which comprises the following steps: reacting a compound of formula (VIII) with a reagent A to generate a compound of formula (VII); reacting the compound in the formula (VII) with a reagent B under the action of a metal reagent M to generate a compound in a formula (VI); reacting the compound of formula VI with a reagent C to generate a compound of formula V; reacting the compound of formula (V) with a reagent D to generate a compound of formula (IV); reacting the compound in the formula IV with a reagent E to generate a compound in a formula III; reacting the compound in the formula (III) with a reagent F to generate a compound in a formula (II); and reacting the compound in the formula (II) with a reagent G to generate the compound in the formula (I). Reaction conditions are mild, the process is easy to control, operation is simple, and industrial large-scale production is
Bibliography:Application Number: CN202110988001