Chimeric antigen receptor CAR or CAR construct targeting BCMA and CD19 and application of chimeric antigen receptor CAR or CAR construct

• Main Authors: CHANG JIANHUI, WANG JINGYI, CAI ZHENZHEN, HOU PANYAN, WANG JIANGMAN, XUE TONGTONG, XIAO LIANG, ZHU YANLIN, JING GUANGJUN, WANG XIAODONG
• Format: Patent
• Language: Chinese; English
• Published: 24.02.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

Provided are a chimeric antigen receptor (CAR) or CAR construct comprising an antibody against BCMA and CD19, as well as a nucleic acid molecule encoding the CAR or CAR construct, a modified immune cell, and a method for preparing the immune cell. The CAR or the CAR construct and the modified immune cell are used for preventing and/or treating B cell related conditions (such as B cell and plasma cell related malignant tumors or autoimmune diseases (such as systemic lupus erythematosus) and the like), target spot escape can be effectively avoided, and recurrence of multiple myeloma is prevented. 提供了一种包含抗BCMA和CD19的抗体的嵌合抗原受体(CAR)或CAR构建体，以及编码该CAR或CAR构建体的核酸分子、经改造的免疫细胞以及制备该免疫细胞的方法。该CAR或CAR构建体和经改造的免疫细胞用于预防和/或治疗B细胞相关病况(例如B细胞及浆细胞相关的恶性肿瘤或自身免疫疾病(如系统性红斑狼疮)等)，能有效避免靶点逃逸，防止多发性骨髓瘤的复发。