RET (transfection rearrangement) for assessment of stroke

• Main Authors: DIETRICH MAXIMILIAN, ZIEGLER ALEXANDER, LOONEY VICTOR, WIENHUES-THELEN URSULA-HENRIKE, SHOTTON URI, KASTNER PETER
• Format: Patent
• Language: Chinese; English
• Published: 03.02.2023
• Subjects: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PHYSICS; TESTING

The present invention relates to a method for assisting in the prediction of stroke and/or dementia in a subject comprising a) determining the amount of biomarker RET (transfection rearrangement) in a sample from the subject, b) comparing the amount determined in step a) to a reference, and c) assisting in the prediction of stroke and/or dementia. The invention further relates to a method for assisting in the assessment of the extent of white matter lesion in a subject, a method for assisting in the assessment of whether a subject has experienced one or more asymptomatic strokes, and a method for assisting in the diagnosis of atrial fibrillation in a subject. The invention further encompasses corresponding uses. 本发明涉及一种用于辅助对受试者的卒中和/或痴呆的预测的方法，所述方法包括a)确定来自受试者的样品中的生物标志物RET(转染重排)的量，b)将步骤a)中确定的量与参考进行比较，并且c)辅助对卒中和/或痴呆的预测。本发明进一步涉及一种用于辅助对受试者的白质病变程度的评估的方法、一种用于辅助评估受试者是否经历过一次或多次无症状性卒中的方法以及一种用于辅助对受试者的心房颤动的诊断的方法。本发明进一步涵盖相应的用途。