2, 4-dioxopyrimidine compounds that inhibit CD73

• Main Authors: CHIN GREGORY F, GOYAL BINDU, HE SHAWN, MACKMAN ROBERT L, SIEGEL DARREN S, ENSON DANIEL, SCHROEDER SCOTT D, SHAPIRO NATALIE D, TANG DAVID T, YANG HONG, CLARK MICHAEL O, MISH MICHAEL R, COSMAN JENNIFER LEIGH, HUI HOWARD C, BARTLETT MARK J
• Format: Patent
• Language: Chinese; English
• Published: 03.02.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present disclosure provides pyrimidinedione compounds and pharmaceutical compositions thereof for the treatment of cancers, including solid tumors. The compounds may be used alone or in combination with other anti-cancer agents. 本公开提供了用于治疗包括实体瘤在内的癌症的嘧啶二酮化合物及其药物组合物。所述化合物可以单独使用或与其他抗癌剂组合使用。