Substituted aminothiazoles as DGKZETA inhibitors for immune activation

• Main Authors: WERBECK NICOLAS, BADER BENJAMIN, DETLEF STOECKIGT, KOSEMUND DIRK, KIRCHHOFF DENNIS, GRACE MICHAEL, NGUYEN THI THU UYEN, SCHMEES NORBERT, ROEHN ULRIKE, BOEMER ULF, NOWAK-REPPEL KATRIN, RINK CHRISTIAN, OWRINGA, REINHOLD, PETERSEN KIRSTIN
• Format: Patent
• Language: Chinese; English
• Published: 03.02.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to aminothiazole compounds of general formula (I), to processes for preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and conjugates comprising said compounds, and the use of said compounds as a sole agent or in combination with other active ingredients for the preparation of a pharmaceutical composition for the treatment and/or prophylaxis of diseases, in particular diacylglycerol kinase zeta (DGK zeta) modulated conditions: wherein R1, R2, R3 and R4 are as defined herein. 本发明涉及通式(I)的氨基噻唑化合物，制备所述化合物的方法，可用于制备所述化合物的中间体化合物，包含所述化合物的药物组合物和结合物，以及所述化合物作为单一药剂或与其他活性成分结合用于制备用于治疗和/或预防疾病的药物组合物的用途，所述疾病特别是二酰基甘油激酶ζ(DGKζ)调节的病症：其中R1、R2、R3和R4如本文所定义。