Application of compound containing tricyclic heteroaryl

• Main Authors: YANG HANYU, ZHANG HANCHENG, LIU XIBAO, CAI CONGCONG, DAN MO, LYU LU, LIU JIERU, QIN NING, ZHANG DANDAN
• Format: Patent
• Language: Chinese; English
• Published: 03.02.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides an application of a compound (I), an optical isomer thereof or a pharmaceutically acceptable salt thereof in preparation of drugs for treating diseases related to high expression or abnormal activation of JAK and SYK kinase, including autoimmune diseases, such as immune-mediated skin diseases, especially psoriasis, atopic dermatitis and SLE (systemic lupus erythematosus). The compound (I), the optical isomer thereof or the pharmaceutically acceptable salt thereof can improve psoriasis, atopic dermatitis and SLE mouse skin lesion, relieve renal injury, inhibit enlargement of immune organs, reduce the inflammation level and inhibit increase of SLE related antibodies and cell factors in serum, has a certain safe therapeutic window, and has a very good clinical application prospect. 本申请提供化合物(I)、其光学异构体或其药学上可接受的盐在制备用于治疗JAK和SYK激酶高表达或异常激活相关疾病，包括自身免疫性疾病，如免疫介导的皮肤病，尤其是银屑病、特应性皮炎和SLE的药物中的用途。本发明所述化合物(I)、其光学异构体或其药学上可接受的盐可改善银屑病、特应性皮炎和SLE小鼠皮肤病变，缓解肾损伤，抑制免疫器官增大，降低炎症水平，抑制血清中SLE相关抗体和细胞因子的增高，且具有一定安全治疗窗，具有很好的