5-oxo-pyrrolidine-3-carboxamides as NAV1.8 inhibitors

• Main Authors: BELL IAN M, SHAH ANKUR A, ARASAPPAN ASHOK, VAN HEYST, MARC, D, LIU HONG, LIU JIAN, COX JASON M, KELLY, MICHAEL, J., III, LAYTON MARK E
• Format: Patent
• Language: Chinese; English
• Published: 03.02.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Novel compounds of structural formula (I), and pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity, and are useful in the treatment, prevention, management, amelioration, control and inhibition of diseases mediated by Nav1.8 channel activity. The compounds of the present invention are useful for treating, preventing or managing pain disorders, cough disorders, acute pruritus disorders and chronic pruritus disorders. 结构式(I)的新型化合物，及其药学上可接受的盐，是Nav1.8通道活性的抑制剂，并且可用于治疗、预防、管理、改善、控制和抑制由Nav1.8通道活性介导的疾病。本发明的化合物可用于治疗、预防或管理疼痛病症、咳嗽病症、急性瘙痒病症和慢性瘙痒病症。