TARS or fragments thereof derived from ackermania muciniphila, and uses thereof

• Main Authors: LEE WON-JAE, LEE EUN YOUNG, LI ZHEHAO, PARK SHIN-HYE, KIM BYUNGAN, LEE KYOUNG-AH, KIM MYEONG-HEE, JIN SHOUWAN, HWANG JUNG-WON
• Format: Patent
• Language: Chinese; English
• Published: 31.01.2023
• Subjects: FODDER; FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

The present invention relates to the use of a threonyl-tRNA synthetase (TARS) derived from Akkermansia muciniphila (Akkermansia muciniphila) or a fragment thereof as an active ingredient for the prevention, alleviation and treatment of inflammatory diseases. The Ackermann muciniphila TARS or a fragment thereof according to the present invention promotes differentiation of M2 macrophages, which are anti-inflammatory macrophages, to expand the macrophages, thereby increasing secretion of IL-10, which is an anti-inflammatory cytokine, resulting in proliferation of B cells, to achieve an anti-inflammatory effect, and to improve the anti-inflammatory effect. And thus demonstrates not only an effect of alleviating inflammatory diseases but also an effect of alleviating immune diseases, infectious diseases, and metabolic diseases associated with inflammation, and has an excellent effect in the prevention or treatment of inflammatory bowel disease (IBD). 本发明涉及源自嗜黏蛋白阿克曼菌(Akkermansia muciniphila)的苏氨酰-tRNA合成酶(TARS)或其片段作