Preparation method of carbetocin

• Main Authors: MO XIAOLUN, QIN LIANGZHENG, CHEN YONGHAN
• Format: Patent
• Language: Chinese; English
• Published: 20.01.2023
• Subjects: CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES

The invention provides a preparation method of carbetocin. The method comprises the following steps: carrying out first mixing treatment on carbetocin crude peptide and an acetonitrile solution; carrying out polymer filler adsorption treatment on the first mixed treatment product; carrying out elution treatment on the polymer filler adsorbed with the first mixed treatment product so as to obtain an eluent; and carrying out purification treatment on the eluent, so as to obtain the carbetocin. By adopting the method, the use of inflammable and explosive reagents such as diethyl ether or methyl tert-butyl ether can be effectively avoided, the safety risk is reduced, the steps of crude peptide precipitation, centrifugation and vacuum drying are reduced, the production time is saved, and the production efficiency is improved. 本发明提出了一种卡贝缩宫素的制备方法，所述方法包括将卡贝缩宫素粗肽与乙腈溶液进行第一混合处理；将第一混合处理产物进行聚合物填料吸附处理；将吸附有第一混合处理产物的聚合物填料进行洗脱处理，以便获得洗脱液；以及将所述洗脱液进行纯化处理，以便获得所述卡贝缩宫素。采用此方法能够有效的避免使用乙醚或甲基叔丁基醚等易燃易爆试剂的使用，降低了安全风险，同时减少了粗肽沉淀，离心及真空干燥的步骤，