Pyridazinyl thiazole carboxamide compound
The invention relates to a pyridazinyl thiazole carboxamide compound. The present invention provides a compound useful as an active ingredient of a pharmaceutical composition for treating cancers associated with immune cell activation or cancers resistant to anti-PD-1 antibody/anti-PD-L1 antibody th...
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| Main Authors | , , , , , , , , |
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| Format | Patent |
| Language | Chinese English |
| Published |
20.01.2023
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The invention relates to a pyridazinyl thiazole carboxamide compound. The present invention provides a compound useful as an active ingredient of a pharmaceutical composition for treating cancers associated with immune cell activation or cancers resistant to anti-PD-1 antibody/anti-PD-L1 antibody therapy. The present inventors studied a compound useful as an active ingredient of a pharmaceutical composition for treating cancers associated with immune cell activation or cancers resistant to anti-PD-1 antibody/anti-PD-L1 antibody therapy, and confirm that a pyridazinyl thiazole carboxamide compound has a DGKzeta (DGKzeta) inhibitory effect, thereby completing the present invention. The pyridazinyl thiazole carboxamide compound of the present invention has a DGK [zeta] inhibitory effect, and can be used as a therapeutic agent for cancers associated with immune cell activation or cancers having resistance to anti-PD-1 antibody/anti-PD-L1 antibody therapy.
本发明涉及哒嗪基噻唑甲酰胺类化合物。本发明提供作为与免疫细胞活化相关的癌症或者对抗PD-1抗体/抗PD-L1抗体疗法 |
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| AbstractList | The invention relates to a pyridazinyl thiazole carboxamide compound. The present invention provides a compound useful as an active ingredient of a pharmaceutical composition for treating cancers associated with immune cell activation or cancers resistant to anti-PD-1 antibody/anti-PD-L1 antibody therapy. The present inventors studied a compound useful as an active ingredient of a pharmaceutical composition for treating cancers associated with immune cell activation or cancers resistant to anti-PD-1 antibody/anti-PD-L1 antibody therapy, and confirm that a pyridazinyl thiazole carboxamide compound has a DGKzeta (DGKzeta) inhibitory effect, thereby completing the present invention. The pyridazinyl thiazole carboxamide compound of the present invention has a DGK [zeta] inhibitory effect, and can be used as a therapeutic agent for cancers associated with immune cell activation or cancers having resistance to anti-PD-1 antibody/anti-PD-L1 antibody therapy.
本发明涉及哒嗪基噻唑甲酰胺类化合物。本发明提供作为与免疫细胞活化相关的癌症或者对抗PD-1抗体/抗PD-L1抗体疗法 |
| Author | SEKI YOHEI IWAI, YOSHINORI NAKAMURA AKIHIKO OKUYAMA KEIICHIRO KUROSAWA KAZUO TOMIYAMA, HIROSHI IKEDA OSAMU MIYASAKA KOZO WATANABE HIDEYUKI |
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| DocumentTitleAlternate | 哒嗪基噻唑甲酰胺类化合物 |
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| Notes | Application Number: CN202211308277 |
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| RelatedCompanies | KOTOBUKI PHARMACEUTICAL CO., LTD ASTELLAS PHARMA INC |
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| Snippet | The invention relates to a pyridazinyl thiazole carboxamide compound. The present invention provides a compound useful as an active ingredient of a... |
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| Title | Pyridazinyl thiazole carboxamide compound |
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