Pyridazinyl thiazole carboxamide compound

• Main Authors: WATANABE HIDEYUKI, TOMIYAMA, HIROSHI, NAKAMURA AKIHIKO, MIYASAKA KOZO, SEKI YOHEI, OKUYAMA KEIICHIRO, KUROSAWA KAZUO, IWAI, YOSHINORI, IKEDA OSAMU
• Format: Patent
• Language: Chinese; English
• Published: 20.01.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to a pyridazinyl thiazole carboxamide compound. The present invention provides a compound useful as an active ingredient of a pharmaceutical composition for treating cancers associated with immune cell activation or cancers resistant to anti-PD-1 antibody/anti-PD-L1 antibody therapy. The present inventors studied a compound useful as an active ingredient of a pharmaceutical composition for treating cancers associated with immune cell activation or cancers resistant to anti-PD-1 antibody/anti-PD-L1 antibody therapy, and confirm that a pyridazinyl thiazole carboxamide compound has a DGKzeta (DGKzeta) inhibitory effect, thereby completing the present invention. The pyridazinyl thiazole carboxamide compound of the present invention has a DGK [zeta] inhibitory effect, and can be used as a therapeutic agent for cancers associated with immune cell activation or cancers having resistance to anti-PD-1 antibody/anti-PD-L1 antibody therapy. 本发明涉及哒嗪基噻唑甲酰胺类化合物。本发明提供作为与免疫细胞活化相关的癌症或者对抗PD-1抗体/抗PD-L1抗体疗法