Aza compound or pharmaceutically acceptable salt thereof as well as preparation method and application of aza compound or pharmaceutically acceptable salt
The invention discloses an aza compound or a pharmaceutically acceptable salt thereof as well as a preparation method and application thereof. The structural formula of the aza compound is shown as a formula (2), wherein X is a carbon atom or a nitrogen atom; n is selected from 1, 2 or 3; r1 is one...
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Format | Patent |
Language | Chinese English |
Published |
17.01.2023
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Abstract | The invention discloses an aza compound or a pharmaceutically acceptable salt thereof as well as a preparation method and application thereof. The structural formula of the aza compound is shown as a formula (2), wherein X is a carbon atom or a nitrogen atom; n is selected from 1, 2 or 3; r1 is one or more groups on a ring A, and R1 is independently selected from hydrogen, halogen, C1-C6 alkyl groups, C1-C6 alkoxy groups, trifluoromethyl, C1-C6 ester groups, C1-C6 alkylamino groups, cyano groups or phenyl groups; when the number of the R1 is more than one, the two R1 can be connected through a saturated or unsaturated C1-C4 carbon chain; r < 2 > is selected from hydrogen, carbobenzoxy, t-butyloxycarbonyl, fluorenylmethoxycarbonyl, phthaloyl, p-toluenesulfonyl, trifluoroacetyl, p-methoxybenzyl, benzyl or methylsulfonyl; and R3 is selected from hydrogen, phenyl or C1-C6 alkyl. The aza compound or the pharmaceutically acceptable salt of the aza compound has the activity of inhibiting COX-2.
本发明公开了一种氮杂类化合物或其药学上可接 |
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AbstractList | The invention discloses an aza compound or a pharmaceutically acceptable salt thereof as well as a preparation method and application thereof. The structural formula of the aza compound is shown as a formula (2), wherein X is a carbon atom or a nitrogen atom; n is selected from 1, 2 or 3; r1 is one or more groups on a ring A, and R1 is independently selected from hydrogen, halogen, C1-C6 alkyl groups, C1-C6 alkoxy groups, trifluoromethyl, C1-C6 ester groups, C1-C6 alkylamino groups, cyano groups or phenyl groups; when the number of the R1 is more than one, the two R1 can be connected through a saturated or unsaturated C1-C4 carbon chain; r < 2 > is selected from hydrogen, carbobenzoxy, t-butyloxycarbonyl, fluorenylmethoxycarbonyl, phthaloyl, p-toluenesulfonyl, trifluoroacetyl, p-methoxybenzyl, benzyl or methylsulfonyl; and R3 is selected from hydrogen, phenyl or C1-C6 alkyl. The aza compound or the pharmaceutically acceptable salt of the aza compound has the activity of inhibiting COX-2.
本发明公开了一种氮杂类化合物或其药学上可接 |
Author | WANG YONGDONG ZHU SHIFA LIU ZIRUI SHI QIU HUANG ZHIPENG |
Author_xml | – fullname: LIU ZIRUI – fullname: WANG YONGDONG – fullname: HUANG ZHIPENG – fullname: SHI QIU – fullname: ZHU SHIFA |
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DocumentTitleAlternate | 一种氮杂䓬类化合物或其药学上可接受的盐及其制备方法和应用 |
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Snippet | The invention discloses an aza compound or a pharmaceutically acceptable salt thereof as well as a preparation method and application thereof. The structural... |
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Title | Aza compound or pharmaceutically acceptable salt thereof as well as preparation method and application of aza compound or pharmaceutically acceptable salt |
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