Aza compound or pharmaceutically acceptable salt thereof as well as preparation method and application of aza compound or pharmaceutically acceptable salt

• Main Authors: LIU ZIRUI, WANG YONGDONG, HUANG ZHIPENG, SHI QIU, ZHU SHIFA
• Format: Patent
• Language: Chinese; English
• Published: 17.01.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses an aza compound or a pharmaceutically acceptable salt thereof as well as a preparation method and application thereof. The structural formula of the aza compound is shown as a formula (2), wherein X is a carbon atom or a nitrogen atom; n is selected from 1, 2 or 3; r1 is one or more groups on a ring A, and R1 is independently selected from hydrogen, halogen, C1-C6 alkyl groups, C1-C6 alkoxy groups, trifluoromethyl, C1-C6 ester groups, C1-C6 alkylamino groups, cyano groups or phenyl groups; when the number of the R1 is more than one, the two R1 can be connected through a saturated or unsaturated C1-C4 carbon chain; r < 2 > is selected from hydrogen, carbobenzoxy, t-butyloxycarbonyl, fluorenylmethoxycarbonyl, phthaloyl, p-toluenesulfonyl, trifluoroacetyl, p-methoxybenzyl, benzyl or methylsulfonyl; and R3 is selected from hydrogen, phenyl or C1-C6 alkyl. The aza compound or the pharmaceutically acceptable salt of the aza compound has the activity of inhibiting COX-2. 本发明公开了一种氮杂类化合物或其药学上可接