Program-controlled exosome tissue repair material and preparation method thereof

• Main Authors: ZHAO QILONG, PENG MINGXING, DU XUEMIN
• Format: Patent
• Language: Chinese; English
• Published: 17.01.2023
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL

The exosome program-controlled tissue repair material comprises a flexible substrate, stem cells growing on the surface of the flexible substrate and hydrogel used for packaging the stem cells on the surface of the flexible substrate, and the stem cells can continuously release exosome vesicles containing bioactive molecules. The flexible substrate can convert external field energy into electricity and stimulate the stem cells growing on the surface of the flexible substrate to directionally guide differentiation, so that the proportion and content of different types of bioactive molecules in the exosome vesicles released by the flexible substrate are regulated and controlled; therefore, the differentiated requirements of tissues and organs on bioactive molecules in different stages of regeneration and repair are met. Compared with an existing tissue repair material based on exosome vesicles, the exosome program-controlled tissue repair material provided by the invention has the advantages that behavior funct