Application of reagent for detecting Prdx1 protein in preparation of early diagnosis/prognosis product for acute organ injury or sepsis

• Main Authors: TAO LIJIAN, MENG JIE, PENG ZHANGZHE, YANG HUIXIANG
• Format: Patent
• Language: Chinese; English
• Published: 13.01.2023
• Subjects: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PHYSICS; TESTING

The invention discloses application of a reagent for detecting a biomarker in a sample in preparation of an early diagnosis/prognosis product for acute organ injury or sepsis. The biomarker comprises Prdx1 protein or a specific antibody of the Prdx1 protein. Experiments show that the expression level of the Prdx1 protein is remarkably increased in organ injury serum or other body fluids or samples such as bronchoalveolar lavage fluid and the like, and the Prdx1 protein is extremely likely to become a clinical target of organ injury; and in the acute hepatic failure, the content of serum Prdx1 protein is increased earlier than that of ALT. The expression level of the Prdx1 is detected by detecting the specific antibody of the Prdx1 protein in sample serum of a subject or other body fluid or samples such as bronchoalveolar lavage fluid, whether the subject suffers from the organ injury or not and the severity of the injury can be effectively judged, and the method has important research significance and clinica