Synthesis and application of phosphatase degradation agent

• Main Authors: XIAO DAIBIAO, DU JING, PENG SHIMING, WANG FEI, XU KEXIN, LIU CHENGCHENG, TAN BIN, AI CHAOWU, LUO TONGCHUAN, YU HUA, LIU XINGTAI, PENG YING, HUO YONGXU, LI XINGHAI, CHEN YUANWEI, FAN LEI
• Format: Patent
• Language: Chinese; English
• Published: 13.01.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides synthesis and application of a phosphatase degradation agent, and belongs to the field of chemical medicines. The phosphatase degradation agent is a compound as shown in a formula I, or a salt thereof, or a deuterated compound thereof, or a stereoisomer thereof, or a solvate thereof, or a hydrate thereof, or a prodrug thereof. The compound disclosed by the invention can be used as a phosphatase degradation agent, particularly as an SHP2 protein degradation agent, can be used for treating malignant diseases such as tumors and the like, and has a good application prospect. 本发明提供了一种磷酸酶降解剂的合成和应用，属于化学医药领域。所述磷酸酶降解剂是式I所示化合物、或其盐、或其氘代化合物、或其立体异构体、或其溶剂合物、或其水合物、或其前药。本发明化合物可作为磷酸酶降解剂，特别是作为SHP2蛋白降解剂，可以治疗肿瘤等恶性疾病，具有良好的应用前景。