Preparation method of N-terminal alkenyl aza-aromatic hydrocarbon

• Main Authors: GUO XIN, GUO CANCHENG, NIE ZHIWEN
• Format: Patent
• Language: Chinese; English
• Published: 13.01.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The invention discloses a preparation method of N-terminal alkenyl aza-arene, which comprises the following step: in the air atmosphere and a dimethyl sulfoxide solvent, carrying out one-pot reaction on aromatic aldehyde and aza-arene under the action of alkali to obtain an N-terminal alkenyl aza-arene compound. Aromatic alkenyl of the N-terminal alkenyl aza-arene compound obtained by the method comes from the raw material aldehyde, but a double-bond carbon atom is added compared with the original aldehyde raw material. In the reaction process, a carbon-oxygen double bond of the raw material aromatic aldehyde is converted into a carbon-carbon double bond, and a hydrogen atom on carbonyl carbon of the aromatic aldehyde is substituted by a nitrogen atom in an aza-aromatic hydrocarbon molecule. The method is wide in raw material source, easy to obtain, green, environment-friendly, low in price, simple to operate and beneficial to industrial production. 本发明公开了一种N-端烯基氮杂芳烃的制备方法，该方法是在大气气氛和二甲亚砜溶剂中，芳醛与氮杂芳烃在碱的作用下进行一锅反应