Synthesis method of alpha-quaternary carbon beta-silicon-based amide

• Main Authors: JIA JIALU, ZHENG YANG, CHEN FEI, YAN ZHONGFEI, LI GANG, LIU SHIYU
• Format: Patent
• Language: Chinese; English
• Published: 10.01.2023
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

The invention relates to a synthesis method of alpha-quaternary carbon beta-silicon-based amide, which comprises the following steps: heating an N-arylsulfonyl acrylamide compound and organosilane in the presence of a catalyst, a di-tert-butyl peroxide compound and a solvent in a pressure-resistant reaction tube to react for 24-48 hours in an inert gas atmosphere to prepare the alpha-quaternary carbon beta-silicon-based amide, the DTBP is di-tert-butyl peroxide, the inert gas is argon or nitrogen, the solvent is tert-butyl alcohol or benzene or benzotrifluoride, and the reaction temperature is 85-130 DEG C. The substrate is easy to prepare, the cheap catalyst is used, and synthesis of the alpha-quaternary carbon beta-silicon-based amide compound with important application potential is achieved through a one-pot method. 一种α-季碳β-硅基酰胺的合成方法，采用N-芳磺酰基丙烯酰胺化合物与有机硅烷在催化剂、二叔丁基过氧化合物、溶剂存在下，于耐压反应管中惰性气体氛围下加热反应24至48小时制取，催化剂为碘化亚铜或氯化亚铜或溴化亚铜，DTBP为二叔丁基过氧化合物，惰性气体为氩气或氮气，溶剂为叔丁醇或苯或三氟甲苯，反应温度在85至130℃。本发明的底物容易制备，使用廉价的催化剂，通过"一锅"法实现了具有重要