Phenylpropionic acid derivative and application thereof

The present invention provides a compound represented by formula (I) and a physiologically acceptable salt thereof, wherein each symbol is as defined in the specification. The compound or the salt thereof has a GPR120 receptor modulating effect after metabolism in vivo, and causes an increase in GLP...

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Bibliographic Details
Main Authors LIU RENMIN, WANG MIN, WEI SHITING, LEI KANG, JI LUSHA, WANG XUEKUN, JI GUOXIA, WANG SHIBEN
Format Patent
LanguageChinese
English
Published 06.01.2023
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides a compound represented by formula (I) and a physiologically acceptable salt thereof, wherein each symbol is as defined in the specification. The compound or the salt thereof has a GPR120 receptor modulating effect after metabolism in vivo, and causes an increase in GLP-1 secretion. And is useful as an insulin secretagogue or a drug for the prevention or treatment of diabetes, metabolic syndrome, diseases related thereto, and the like. 本发明提供式（I）表示的化合物及其生理学可接受盐，其中各个符号如说明书中所定义。所述化合物或其盐在体内代谢后具有GPR120受体调节作用，引起GLP-1分泌增加。并且作为胰岛素促分泌素或预防或治疗糖尿病、代谢综合征、及其相关疾病等的药物是有用的（I）。
Bibliography:Application Number: CN202211264163