Double-layer hydrogel dressing as well as preparation method and application thereof

• Main Authors: CHENG XIAOKAI, YANG TIANBAO, ZHANG XILONG, ZHANG JIE, LI HUANHUAN, GOU HONGPENG, YU YAO, JI SHENGYAN, YU JINGJING, LIU CHAO
• Format: Patent
• Language: Chinese; English
• Published: 06.01.2023
• Subjects: AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; CHEMISTRY; COMPOSITIONS BASED THEREON; COMPOSITIONS OF MACROMOLECULAR COMPOUNDS; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; GENERAL PROCESSES OF COMPOUNDING; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; WORKING-UP

The invention provides a double-layer hydrogel dressing and a preparation method and application thereof, the double-layer hydrogel dressing comprises an inner layer and an outer layer, the inner layer comprises the following raw materials: chitosan sulfate and derivatives thereof, a cross-linking agent and a bioactive filler; the outer layer comprises the following raw materials: natural polysaccharide, a film-forming agent and an organic solvent. The chitosan sulfate, the derivative of the chitosan sulfate and the cross-linking agent adopted by the invention have the advantages of high biological activity, biodegradability and wound promotion effect, and a good environment is provided for rapid repair of wounds. The graphene oxide has a good antibacterial effect, can effectively avoid inflammation, abscess and the like in the wound healing process, and reduces the risk of wound infection. According to the dressing, the wound can be quickly closed, and an effective and quick treatment mode is provided for da