Indocyanine derivative and preparation and application thereof
The invention discloses an indocyanine derivative as well as preparation and application thereof, the indocyanine derivative has the following structural formula: the preparation method comprises the step of carrying out Knoevenagel condensation reaction on 2, 3, 3-trimethyl-4, 5-benzoindole and a c...
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Main Authors | , , , , |
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Format | Patent |
Language | Chinese English |
Published |
03.01.2023
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Subjects | |
Online Access | Get full text |
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Summary: | The invention discloses an indocyanine derivative as well as preparation and application thereof, the indocyanine derivative has the following structural formula: the preparation method comprises the step of carrying out Knoevenagel condensation reaction on 2, 3, 3-trimethyl-4, 5-benzoindole and a corresponding electron withdrawing or electron donating group to prepare the indocyanine derivative. The fluorescence intensity of the indocyanine derivative is increased along with the increase of pH, and the indocyanine derivative has large Stokes shift, has the advantages of low background interference and high detection sensitivity during fluorescence analysis, and also has good water solubility and excellent anti-interference performance and fluorescence reversibility. By combining different groups, the pH detection range of the probe can be from pH 1.0 to 6.0, the requirement of cell imaging under the acidic condition is met, and the probe can be used as a tumor cell imaging fluorescent probe.
本发明公开了一种吲哚菁类衍生物及 |
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Bibliography: | Application Number: CN202211100838 |