Macrocyclic inhibitors of peptidyl arginine deiminase

• Main Authors: CANALES EDUARDO Y, PERREAUT SYLVAIN, VAN VELHUIZEN JOZEF JOHANNES, DEBIEN LOUIS PHILIPPE, TAYLOR JAMES G, SZETO RICHARD DAVID, SANGHI MANOJ S, LOYER-DREW JENNIFER ALISON, BYUN HYUN-JU, SHATZKIKH MICHAEL E, TEO WEE KEONG, JANSA PETR, TREIBERG JENNIFER A, PHILLIPS GARY B, MARTINEZ LOUIS P, SCHRIER ADAM J
• Format: Patent
• Language: Chinese; English
• Published: 30.12.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present disclosure relates to novel compounds for the therapeutic treatment of diseases associated with peptidyl arginine deiminase (PAD), such as peptidyl arginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for preparing such compounds, methods o...