Macrocyclic inhibitors of peptidyl arginine deiminase

• Main Authors: CANALES EDUARDO Y, PERREAUT SYLVAIN, VAN VELHUIZEN JOZEF JOHANNES, DEBIEN LOUIS PHILIPPE, TAYLOR JAMES G, SZETO RICHARD DAVID, SANGHI MANOJ S, LOYER-DREW JENNIFER ALISON, BYUN HYUN-JU, SHATZKIKH MICHAEL E, TEO WEE KEONG, JANSA PETR, TREIBERG JENNIFER A, PHILLIPS GARY B, MARTINEZ LOUIS P, SCHRIER ADAM J
• Format: Patent
• Language: Chinese; English
• Published: 30.12.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present disclosure relates to novel compounds for the therapeutic treatment of diseases associated with peptidyl arginine deiminase (PAD), such as peptidyl arginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for preparing such compounds, methods of using such compounds, and pharmaceutical compositions comprising the compounds described herein. 本公开涉及用于治疗性治疗与肽基精氨酸脱亚胺酶(PAD)诸如肽基精氨酸脱亚胺酶4型(PAD4)相关的疾病的新化合物。本公开还涉及用于制备此类化合物的方法和中间体、使用此类化合物的方法和包含本文所述的化合物的药物组合物。