MEASUREMENT OF IMMUNOSTIMULATION RESPONSIVENESS OF IMMUNOCELLS, DETERMINATION OF IMMUNOSYNAPE FORMING

• Main Authors: YANAGIDA MASATOSHI, MIWA KEIKO, OKA YUMA
• Format: Patent
• Language: Chinese; English
• Published: 23.12.2022
• Subjects: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PHYSICS; TESTING

The present invention relates to the measurement of immune stimulus responsiveness of immune cells, the determination of immune synaptic formation ability of immune cells, and a cell analyzer. A method for measuring immunostimulatory responsiveness of an immune cell comprises: (i) a step for bringing an immune cell to be measured into contact with an immunostimulatory factor; (ii) a step for forming a contact surface between the immune cell of the measurement subject and a substance different from the immune cell of the measurement subject; (iii) a step in which the immune cells to be measured are brought into contact with a capture body that binds to the surface antigen on the contact surface and is capable of generating an optical signal; (iv) a step for detecting an optical signal generated by the capturing body; and (v) a step for determining, on the basis of the detected optical signal, whether or not the immune cell of the measurement subject whose contact surface has been released prior to the detectio