Integrated Raman sensor for rapidly detecting new coronavirus based on optical flow control type microstructure optical fiber and SERS (Surface Enhanced Raman Scattering) substrate

• Main Authors: LUO MENG, GAO DANHENG, WANG YUHAN, ZHU ZHENG, YANG XINGHUA, TENG PINGPING, ZHANG YANG
• Format: Patent
• Language: Chinese; English
• Published: 23.12.2022
• Subjects: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PHYSICS; TESTING

The invention provides an integrated Raman sensor for rapidly detecting new coronavirus based on an optical flow control type microstructure optical fiber and an SERS (Surface Enhanced Raman Scattering) substrate. A preparation method of the integrated Raman sensor comprises the following steps: step 1, preparing nano-silver sol by a sol-gel method; 2, nano graphene oxide is connected through a chemical bonding method; step 3, growth of nano-gold particles; 4, modifying the microstructure optical fiber; 5, modifying the microstructure optical fiber in the acceptor domain; and 6, preparing the Raman detection device. According to the invention, the SERS substrate which is specifically combined with the SARS-CoV-2 spike protein is prepared and is combined with the hollow optical fiber to form the optical flow control Raman detector, so that the rapid detection of the SARS-CoV-2 spike protein is realized. The microfluidic Raman SARS-CoV-2 spike protein sensor disclosed by the invention has the advantages of high