Synthesis method of elvin precursor

• Main Authors: SHI CHANGQING, WANG ZHAOWEI
• Format: Patent
• Language: Chinese; English
• Published: 23.12.2022
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The invention discloses a synthesis method of an elvin hormone precursor. The preparation method comprises the following steps: S1, protecting amino of ethanolamine by using phthaloyl to obtain a compound A; s2, etherifying the compound A obtained in the step S1 and bromoacetal under the action of sodium hydrogen to obtain an ether compound B; s3, condensing and isomerizing the ether compound B obtained in the step S2 and hydantoin under an alkaline condition to obtain a compound C; s4, hydrolyzing the compound C obtained in the step S3 to obtain a compound D; and S5, removing a protecting group from the compound D obtained in the step S4, so as to obtain the racemic artemisia vulgaris hormone precursor TM. The synthesis route of the muvin hormone precursor is simpler, and the synthesis of the muvin hormone precursor can be completed by five steps; the method has the advantages of cheap and easily available raw materials, simple process operation, high yield and industrial amplification potential. 本发明公开了一种艾维激