Arctigenin liquid nano preparation and preparation method thereof

• Main Authors: HE BIN, RAN ZHIPING, ZHOU QI, WU LIJUN, LIU WEI, DU KANGYU, CHEN XIABING, LU ZHENG, CHEN GUOMING, YANG WENHAI, LIU DONGQING, LI YING, SHAO ZHIYONG, LIU WU
• Format: Patent
• Language: Chinese; English
• Published: 23.12.2022
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides an arctigenin liquid nano preparation and a preparation method thereof, and relates to the technical field of pharmaceutical preparations. The arctigenin is prepared into the liquid nano-preparation, the particle size of liquid drops is distributed in a nano level, the specific surface area is obviously increased, and the arctigenin nano-preparation has the advantages of being fast in absorption and high in bioavailability. Meanwhile, the nano preparation entering the body can be captured by migrated leukocytes, and the medicine is carried to an inflammatory focus through chemotactic action, so that the arctigenin medicine has the characteristic of targeted administration, and the treatment is more targeted. Besides, the arctigenin is dissolved in the oil phase, and then the oil phase is dissolved in the water in an emulsifying manner, so that the arctigenin is also dissolved in the water, the solubility of the arctigenin in the water is improved, on one hand, the bioavailability is imp