Synthesis method of 2-methyl-4, 5, 6-trichloropyrimidine

• Main Authors: WANG AILING, ZHENG XUEFANG, JIANG DESHENG, KANG YUEPING, ZHANG YIWEN
• Format: Patent
• Language: Chinese; English
• Published: 20.12.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The invention belongs to the field of fine chemical intermediates, and discloses a synthesis method of 2-methyl-4, 5, 6-trichloropyrimidine, which comprises the following steps: by taking 2-methyl-5-bromo-4, 6-dihydroxypyrimidine and phosphorus oxychloride as raw materials, carrying out oil bath heating to reflux internal temperature of 105 DEG C, carrying out substitution reaction, and filtering and drying to obtain the 2-methyl-4, 5, 6-trichloropyrimidine. The biggest characteristic of the technical route is that the phosphorus oxychloride chlorination step not only replaces hydroxyl with chlorine, but also replaces bromine with chlorine, so that the target compound is synthesized by a one-pot method. The route design is novel and is not reported in literatures. The process route is skillful, simple and convenient to select, easy to operate and low in cost. 本发明属于精细化工中间体领域，公开了一种2-甲基-4,5,6-三氯嘧啶的合成方法，以2-甲基-5-溴-4,6-二羟基嘧啶和三氯氧磷为原料，油浴加热到回流内温105℃条件下进行取代反应，再经过滤干燥处理得到2-甲基-4,5,6-三氯嘧啶。本发明技术路线的最大特点是三氯氧磷氯化步骤不但将羟基取代为氯，且溴也